Although in different soils under different conditions around the world, gypsum is used correctly to correct soil pH, improve soil condition and increase yield, only special directed uses are appropriate for the north-central region.

Gypsum is not an effective liming product in the region. Gypsum can improve soil condition if the soil is dispersive due to excessive sodium. Sodic soils can be improved with gypsum if the appropriate rate is applied, the gypsum is worked into the soil to a deep depth, tile is present and rainfall or irrigation moves the sodium out of the system. Gypsum has decreased iron chlorosis on some soils in Nebraska, but the effects are inconsistent and generally are not recommended in place of iron amendments.

Gypsum may be used as a source of sulfur, although its relatively low solubility, compared with other sulfur sources, may be a concern in more arid parts of the region.